Women who are drug users, but stop before pregnancy, still run the risk of affecting not only their own children but their grandchildren as well. A new study shows that certain addictive drugs can alter the brain chemistry of offspring, in generations down the line.
Scientists recently conducted experiments on female rats. They exposed the rodents to morphine for ten days when the rats were in their adolescent years. Then, after three weeks of no drugs, the rats mated with healthy, drug-free males. Researchers found that their offspring produced a lesser quantity of dopamine, an important chemical messenger in the brain. This area of the brain is associated with reward-seeking behavior and chemical addiction. The next generation of grandchildren rats also exhibited a similar deficit of dopamine.
So far, it appears that the dopamine levels of male offspring are most affected by drug use in child-bearing women. Imbalances in the brain’s dopamine levels are linked to mental illness and problems with addiction.
In part two of the study, scientists exposed the offspring to a substance that imitates a dopamine-induced elevated release of stress hormones, which indicates that the rat’s abilities to control stress had been affected.
This research is important because it is helping researchers understand how the effects of drug use are passed on to subsequent generations, down to the genetic level. Understanding how gene expression, and the production of protein, is affected by substance abuse provides clues to how multi-generational changes in brain chemistry make offspring more susceptible to drug addiction.
Studies like these will eventually help treatment centers and doctors provide more effective drug counseling solutions, and help educators teach young people the importance of avoiding drug use. Anyone struggling with chemical dependency issues, and friends and family of those dependent on drugs or alcohol, can utilize sites like Rehab-International.org to learn more about how they can get help for their addictions.







